In this study, a new method based on homogeneous liquid–phase microextraction was developed for the determination of methamphetamine (MA) in urine samples. Dipropylamine (DPA), as a solvent with switchable hydrophilicity, was used as the extraction solvent and can be miscible/immiscible based on variable pH values of the aqueous sample solution. The effects of operational extraction parameters such as DPA volume, temperature, the amount of added acid and base solutions, and NaCl content of the sample were investigated. Under optimal conditions the preconcentration factor, limit of detection and linearity of the method were achieved in the ranges of 98.8, 1.5 µgL⁻¹ and 5–1500 µgL⁻¹, respectively. Also, within-run precision, between-run precision and robustness of the method were investigated. Finally, the proposed method was successfully applied to the analysis of MA in urine sample.

在这项研究中，开发了一种基于均相液相微萃取的新方法，用于测定尿液样品中的甲基苯丙胺（MA）。二丙胺（DPA）作为具有可转换亲水性的溶剂，被用作提取溶剂，并且根据样品水溶液的可变pH值可以互溶/不互溶。研究了操作提取参数（如DPA体积，温度，添加的酸和碱溶液的量以及样品中NaCl含量）的影响。在最佳条件下，该方法的预浓系数，检测限和线性度分别达到98.8、1.5 µgL ^-1和5–1500 µgL ^-1， 分别。此外，研究了该方法的批内精密度，批间精密度和鲁棒性。最终，该方法成功地应用于尿液中MA的分析。