Thermoresponsive Hydrogels Based on Telechelic Polyelectrolytes: From Dynamic to “Frozen” Networks,Macromolecules

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Thermoresponsive Hydrogels Based on Telechelic Polyelectrolytes: From Dynamic to “Frozen” Networks
Macromolecules ( IF 5.1 ) Pub Date : 2018-03-06 00:00:00 , DOI: 10.1021/acs.macromol.8b00193
Constantinos Tsitsilianis ₁ , George Serras ₁ , Chia-Hsin Ko ₂ , Florian Jung ₂ , Christine M. Papadakis ₂ , Maria Rikkou-Kalourkoti ₃ , Costas S. Patrickios ₃ , Ralf Schweins ₄ , Christophe Chassenieux ₅

Affiliation

A novel thermoresponsive gelator of (B-co-C)-b-A-b-(B-co-C) topology, comprising a poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) weak polyelectrolyte as central block, end-capped by thermosensitive poly(triethylene glycol methyl ether methacrylate/n-butyl methacrylate) [P(TEGMA-co-nBuMA)] random copolymers, was designed and explored in aqueous media. The main target of this design was to control the dynamics of the stickers by temperature as to create an injectable hydrogel that behaves as a weak gel at low temperature and as a strong gel at physiological temperature. Indeed, at low temperatures, the system behaves like a viscoelastic complex fluid (dynamic network), while at higher temperatures, an elastic hydrogel is formed (“frozen” network). The viscosity increases exponentially upon heating, about 5 orders of magnitude from 5 to 45 °C, which is attributed to the exponential increase of the lifetime of the self-assembled stickers. The integration of thermo- and shear responsive properties in the gelator endows the gel with injectability. Moreover, the gel can be rapidly recovered upon cessation of the applied stress at 37 °C, simulating conditions similar to those of injection through a 28-gauge syringe needle. All these hydrogel properties render it a good candidate for potential applications in cell transplantation through injection strategies.

中文翻译：

基于遥螯聚电解质的热敏水凝胶：从动态网络到“冻结”网络

（B-的一种新颖的热响应凝胶化剂共- -C）b -A- b - （B-共-C）的拓扑结构，其包括聚（2-（二甲基氨基）乙基甲基丙烯酸酯）（PDMAEMA）弱聚电解质为中心嵌段，端-由热敏性聚（三乙二醇甲基丙烯酸甲酯/甲基丙烯酸正丁酯）[P（TEGMA- co - n（BuMA）]无规共聚物，是在水性介质中设计和研究的。该设计的主要目标是通过温度控制粘贴物的动力学，以产生可注射的水凝胶，该水凝胶在低温下表现为弱凝胶，在生理温度下表现为强凝胶。实际上，在低温下，系统的行为就像粘弹性复杂流体（动态网络），而在高温下，会形成弹性水凝胶（“冻结”网络）。加热后粘度呈指数增长，从5到45°C大约增加5个数量级，这归因于自组装胶粘剂的使用寿命呈指数增长。凝胶器中热响应和剪切响应特性的整合使凝胶具有可注射性。而且，当在37°C停止施加应力时，可以模拟与通过28号注射器针头注射的条件相似的条件，从而迅速恢复凝胶。所有这些水凝胶特性使其成为通过注射策略在细胞移植中潜在应用的良好候选者。

更新日期：2018-03-06

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