C–H Amination of Purine Derivatives via Radical Oxidative Coupling,The Journal of Organic Chemistry

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C–H Amination of Purine Derivatives via Radical Oxidative Coupling
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2018-03-06 00:00:00 , DOI: 10.1021/acs.joc.8b00066
Zheng Luo ₁ , Ziyang Jiang ₁ , Wei Jiang ₁ , Dongen Lin ₁

Affiliation

An oxidative coupling reaction between purines and alkyl ethers/benzyl compounds was developed to synthesize a series of N9 alkylated purine derivatives using n-Bu₄NI as a catalyst and t-BuOOH as an oxidant. This protocol uses commercially available, inexpensive catalysts and oxidants and has a wide range of substrates with a simple operation.

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