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Lycopene Supplementation Attenuates Oxidative Stress, Neuroinflammation, and Cognitive Impairment in Aged CD-1 Mice
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2018-03-06 00:00:00 , DOI: 10.1021/acs.jafc.7b05770 Beita Zhao 1 , Hua Liu 1 , Jiamin Wang 1 , Pujie Liu 1 , Xintong Tan 1 , Bo Ren 1 , Zhigang Liu 1 , Xuebo Liu 1
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2018-03-06 00:00:00 , DOI: 10.1021/acs.jafc.7b05770 Beita Zhao 1 , Hua Liu 1 , Jiamin Wang 1 , Pujie Liu 1 , Xintong Tan 1 , Bo Ren 1 , Zhigang Liu 1 , Xuebo Liu 1
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The carotenoid pigment lycopene (LYC) possesses several properties, including antioxidative, anti-inflammatory, and neuroprotective properties. This study examined the effects of dietary supplementation with LYC on age-induced cognitive impairment, and the potential underlying mechanisms. Behavioral tests revealed that chronic LYC supplementation alleviated age-associated memory loss and cognitive defects. Histological and immunofluorescence-staining results indicated that LYC treatment reversed age-associated neuronal damage and synaptic dysfunctions in the brain. Additionally, LYC supplementation decreased age-associated oxidative stress via suppression of malondialdehyde levels, which increased glutathione, catalase, and superoxide dismutase activities and the levels of antioxidant-enzyme mRNAs, including those of heme oxygenase 1 and NAD-(P)-H–quinone oxidoreductase-1. Furthermore, LYC supplementation significantly reduced age-associated neuroinflammation by inhibiting microgliosis (Iba-1) and downregulating related inflammatory mediators. Moreover, LYC lowered the accumulation of Aβ1–42 in the brains of aged CD-1 mice. Therefore, LYC has the potential for use in the treatment of several age-associated chronic diseases.
中文翻译：
番茄红素补充剂可减轻CD-1老年小鼠的氧化应激，神经炎症和认知障碍。
类胡萝卜素色素番茄红素（LYC）具有多种特性，包括抗氧化，抗炎和神经保护特性。这项研究检查了饮食中添加LYC对年龄引起的认知障碍的影响以及潜在的潜在机制。行为测试表明，长期补充LYC可以减轻与年龄相关的记忆力丧失和认知缺陷。组织学和免疫荧光染色结果表明，LYC治疗可逆转大脑中与年龄相关的神经元损伤和突触功能障碍。此外，LYC的补充通过抑制丙二醛水平降低了与年龄相关的氧化应激，这增加了谷胱甘肽，过氧化氢酶和超氧化物歧化酶的活性以及抗氧化酶mRNA的水平，包括血红素加氧酶1和NAD-（P）-H-醌氧化还原酶-1。此外，LYC补充剂通过抑制小胶质细胞增生（Iba-1）和下调相关的炎症介质，显着减少了与年龄相关的神经炎症。此外，LYC降低了Aβ的积累在CD-1老年小鼠的大脑中为1–42。因此，LYC具有治疗多种与年龄相关的慢性疾病的潜力。
更新日期：2018-03-06
中文翻译：
番茄红素补充剂可减轻CD-1老年小鼠的氧化应激，神经炎症和认知障碍。
类胡萝卜素色素番茄红素（LYC）具有多种特性，包括抗氧化，抗炎和神经保护特性。这项研究检查了饮食中添加LYC对年龄引起的认知障碍的影响以及潜在的潜在机制。行为测试表明，长期补充LYC可以减轻与年龄相关的记忆力丧失和认知缺陷。组织学和免疫荧光染色结果表明，LYC治疗可逆转大脑中与年龄相关的神经元损伤和突触功能障碍。此外，LYC的补充通过抑制丙二醛水平降低了与年龄相关的氧化应激，这增加了谷胱甘肽，过氧化氢酶和超氧化物歧化酶的活性以及抗氧化酶mRNA的水平，包括血红素加氧酶1和NAD-（P）-H-醌氧化还原酶-1。此外，LYC补充剂通过抑制小胶质细胞增生（Iba-1）和下调相关的炎症介质，显着减少了与年龄相关的神经炎症。此外，LYC降低了Aβ的积累在CD-1老年小鼠的大脑中为1–42。因此，LYC具有治疗多种与年龄相关的慢性疾病的潜力。
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