Background

Chemical peels have shown efficacy in the treatment of acne, photoaging, and pigmentary dyschromias; however, studies evaluating side effects, particularly in patients with skin of color, are limited.

Objective

We sought to determine the frequency of side effects and complications associated with superficial chemical peels in patients with skin types III-VI.

Methods

A 5-year single center retrospective analysis was performed.

Results

Of 473 chemical peel treatments included in this study, 18 (3.8%) were associated with short-term (≤2 weeks) or long-term (>2 weeks) complications. The most frequent complications were crusting (2.3%), postinflammatory hyperpigmentation (1.9%), and erythema (1.9%). All side effects resolved within 8 months of treatment and were located on the face. When stratified by season, side effects were noted to be less common during the winter. In the adjusted model, Fitzpatrick skin type VI was associated with a higher odds of side effects (odds ratio 5.14, 95% confidence interval 1.21-21.8; P = .0118).

Limitations

Single center retrospective design.

Conclusion

In this study, superficial chemical peels performed on patients with skin types III-VI had a relatively low complication rate, and skin type VI had higher odds of experiencing an adverse event. Side effects were noted to be less frequent during the winter months.

中文翻译：

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评估深色皮肤浅表化学剥离的安全性：一项回顾性研究

背景

化学果皮已显示出治疗痤疮，光老化和色素性色素减退的功效。但是，评估副作用的研究非常有限，特别是在有色皮肤的患者中。

客观的

我们试图确定III-VI型皮肤患者中与浅表化学剥离有关的副作用和并发症的发生频率。

方法

进行了为期5年的单中心回顾性分析。

结果

在这项研究中包括的473种化学剥离疗法中，有18种（3.8％）与短期（≤2周）或长期（> 2周）并发症相关。最常见的并发症是结cru（2.3％），发炎后色素沉着（1.9％）和红斑（1.9％）。所有副作用均在治疗后8个月内解决，并且位于面部。当按季节分层时，副作用在冬季较少见。在调整后的模型中，费兹帕特里克皮肤类型VI与更高的副作用几率相关（赔率5.14，95％置信区间1.21-21.8；P  = 0.011）。

局限性

单中心回顾性设计。

结论

在这项研究中，对III-VI型皮肤患者进行表面化学剥离的并发症发生率相对较低，VI型皮肤发生不良事件的几率更高。据指出，在冬季，副作用较少。