Noninvasive Multimodal Imaging of Osteosarcoma and Lymph Nodes Using a 99mTc-Labeled Biomineralization Nanoprobe,Analytical Chemistry

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Noninvasive Multimodal Imaging of Osteosarcoma and Lymph Nodes Using a 99mTc-Labeled Biomineralization Nanoprobe
Analytical Chemistry ( IF 6.7 ) Pub Date : 2018-03-05 00:00:00 , DOI: 10.1021/acs.analchem.7b04925
Zhiming Xu _{1,

2} , Yangyun Wang ₁ , Jianshan Han ₂ , Qingqing Xu ₁ , Jiawei Ren ₁ , Jiaying Xu ₁ , Yong Wang ₁ , Zhifang Chai ₁

Affiliation

The accurate imaging of the lymph nodes represents a critical indicator for tumor staging and surgical planning (e.g., osteosarcoma). Clinically, nodal tracing using a radio-nanocolloid is often limited by the inaccessibility of real-time images and inadequate anatomical information. Herein, we present a ^99mTc-labeled biomineralization nanoprobe for the advanced detection of osteosarcoma and lymph nodes with multimodal imaging. Through the exploitation of the complementary strengths of MRI/SPECT/NIR fluorescence, the fabricated nanoprobe exhibited suitable stability and biocompatibility characteristics and was shown to be able to be located in osteosarcoma. The lymphatic drainage and network in healthy mice were imaged in real-time using NIR fluorescence and SPECT/CT. Furthermore, we demonstrated that our ^99mTc-biomineralization nanoprobe could be used for the high-resolution and high-sensitivity imaging analysis of lymphatic drainage in an orthotopic osteosarcoma model. Overall, the ^99mTc-labeled biomineralization nanoprobe features promising characteristics to be used as an intraoperative visualization tool to aid in precise tumor imaging and nodal resection.

中文翻译：

使用^99m Tc标签的生物矿化纳米探针对骨肉瘤和淋巴结进行无创多模态成像

淋巴结的准确成像代表了肿瘤分期和手术计划（例如，骨肉瘤）的关键指标。临床上，使用无线电纳米胶体进行节点追踪通常受到实时图像难以获取和解剖信息不足的限制。在本文中，我们提出了一种^99m Tc标记的生物矿化纳米探针，用于通过多模态成像进行骨肉瘤和淋巴结的先进检测。通过利用MRI / SPECT / NIR荧光的互补强度，所制造的纳米探针显示出合适的稳定性和生物相容性特征，并被证明能够位于骨肉瘤中。使用NIR荧光和SPECT / CT对健康小鼠的淋巴引流和网络进行实时成像。此外，我们证明了我们的^99m Tc-生物矿化纳米探针可用于原位骨肉瘤模型中淋巴引流的高分辨率和高灵敏度成像分析。总体而言，^99m Tc标记的生物矿化纳米探针具有令人鼓舞的特性，可被用作术中可视化工具，以帮助进行精确的肿瘤成像和淋巴结切除。

更新日期：2018-03-05

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