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Defusing inflammasomes
Journal of Experimental Medicine ( IF 12.6 ) Pub Date : 2018-03-05 , DOI: 10.1084/jem.20180241 Andrew Sandstrom 1 , Russell E Vance 1
中文翻译:
消除炎症小体
更新日期:2018-03-06
Journal of Experimental Medicine ( IF 12.6 ) Pub Date : 2018-03-05 , DOI: 10.1084/jem.20180241 Andrew Sandstrom 1 , Russell E Vance 1
Affiliation
In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation. Surprisingly, they find that caspase-1 is quickly inactivated upon autoproteolytic processing.
中文翻译:
消除炎症小体
在本期《JEM》中,Boucher 等人。(https://doi.org/10.1084/jem.20172222) 报道了炎症小体激活后从巨噬细胞中分离出活性 caspase-1。令人惊讶的是,他们发现 caspase-1 在自蛋白水解过程中很快失活。