The construction of stimuli‐responsive materials by using naturally occurring molecules as building blocks has received increasing attention owing to their bioavailability, biocompatibility, and biodegradability. Herein, a symmetrical azobenzene‐functionalized natural glycyrrhizic acid (trans‐GAG) was synthesized and could form stable supramolecular gels in DMSO/H₂O and MeOH/H₂O. Owing to trans–cis isomerization, this gel exhibited typical light‐responsive behavior that led to a reversible gel–sol transition accompanied by a variation in morphology and rheology. Additionally, this trans‐GAG gel displayed a distinct injectable self‐healing property and outstanding biocompatibility. This work provides a simple yet rational strategy to fabricate stimuli‐responsive materials from naturally occurring, eco‐friendly molecules.

中文翻译：

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天然甘草酸配位的光响应胶凝剂

由于其生物利用度，生物相容性和生物降解性，通过使用天然存在的分子作为结构单元来构建刺激反应材料受到了越来越多的关注。在此，合成了对称的偶氮苯官能化的天然甘草酸（trans - GAG），可以在DMSO / H ₂ O和MeOH / H ₂ O中形成稳定的超分子凝胶。由于反式-顺式异构化，该凝胶表现出典型的光响应性行为导致可逆的凝胶-溶胶转变，并伴随着形态和流变学的变化。此外，该反式- GAG凝胶显示出独特的可注射自我修复特性和出色的生物相容性。这项工作提供了一种简单而合理的策略，可以从天然存在的，生态友好的分子中制备刺激反应的材料。