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Optical trapping-Raman spectroscopy (OT-RS) with embedded microscopy imaging for concurrent characterization and monitoring of physical and chemical properties of single particles
Analytica Chimica Acta ( IF 5.7 ) Pub Date : 2018-08-01 , DOI: 10.1016/j.aca.2018.02.062
Zhiyong Gong , Yong-Le Pan , Gorden Videen , Chuji Wang

The study of physical and chemical properties of a microscopic object, such as a single particle, is made possible using optical trapping (OT) technology combined with other measuring techniques. Here we show a universal optical trap combined with Raman spectroscopy (RS) and microscopy imaging for single-particle studies. The universal optical trap is constructed using two counter-propagating hollow beams and is able to stably levitate single particles of a wide range of properties, such as transparent or absorbing materials, organic (polymers, bioaerosols, etc.) or inorganic constituents (carbon, silica, glass, etc.), and spherical or irregularly shaped morphologies. Both physical and chemical properties and their temporal evolution of the trapped particle can be characterized simultaneously using the integrated OT-RS and imaging system. We created three sample cases to demonstrate the analytical merits of the system: (I) a single particle with no change, (II) partially degraded over the measuring period, and (III) one part from the fragmentized single particle. The particles' chemical compositions, crystalline states, etc. are inferred from their Raman spectra, while their physical properties (sizes, shapes, morphologies, etc.) are revealed by images. This integrated OT-RS system provides a new approach to concurrently characterize and monitor physical and chemical properties of single micrometer-sized objects optically trapped in air.

中文翻译:

光学捕获拉曼光谱 (OT-RS) 与嵌入式显微镜成像,用于同时表征和监测单个粒子的物理和化学特性

使用光学俘获 (OT) 技术与其他测量技术相结合,可以研究微观物体(例如单个粒子)的物理和化学特性。在这里,我们展示了一种与拉曼光谱 (RS) 和显微镜成像相结合的通用光阱,用于单粒子研究。通用光阱由两个反向传播的空心光束构成,能够稳定地悬浮具有多种特性的单个粒子,例如透明或吸收材料、有机物(聚合物、生物气溶胶等)或无机成分(碳、二氧化硅、玻璃等),以及球形或不规则形状的形态。使用集成的 OT-RS 和成像系统,可以同时表征被捕获粒子的物理和化学性质及其时间演变。我们创建了三个示例案例来证明系统的分析优点:(I) 没有变化的单个粒子,(II) 在测量期间部分降解,以及 (III) 来自碎片化单个粒子的一部分。粒子的化学成分、结晶状态等是从它们的拉曼光谱推断出来的,而它们的物理特性(大小、形状、形态等)则通过图像来揭示。这种集成的 OT-RS 系统提供了一种新方法,可以同时表征和监测被光学捕获在空气中的单个微米级物体的物理和化学特性。化学成分、结晶状态等是从它们的拉曼光谱推断出来的,而它们的物理特性(大小、形状、形态等)则通过图像来揭示。这种集成的 OT-RS 系统提供了一种新方法,可以同时表征和监测被光学捕获在空气中的单个微米级物体的物理和化学特性。化学成分、结晶状态等是从它们的拉曼光谱推断出来的,而它们的物理特性(大小、形状、形态等)则通过图像来揭示。这种集成的 OT-RS 系统提供了一种新方法,可以同时表征和监测空气中光学捕获的单个微米级物体的物理和化学特性。
更新日期:2018-08-01
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