Bioorganic Chemistry ( IF 4.5 ) Pub Date : 2018-03-03 , DOI: 10.1016/j.bioorg.2018.03.004 Haitham Elleuch , Wafa Mihoubi , Mohamed Mihoubi , Emna Ketata , Ali Gargouri , Farhat Rezgui
The wide variety of potent biological activities of Morita-Baylis-Hillman adducts (MBH) encouraged us to synthesize new series of products belonging to this class of compounds, possessing different functionalities and exhibiting potential antioxidant activity.
As part of our on-going program on targeting molecules with antioxidant activity, we describe herein different DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging activities of MBH alcohols and their derivatives including acetates, phosphonates and hydrazonophosphonates. The obtained results showed that the strongest DPPH radical scavenging activity was observed in the case of hydrazonophosphonates in comparison to the other MBH derivatives.
中文翻译:
Morita-Baylis-Hillman加合物的潜在抗氧化活性
Morita-Baylis-Hillman加合物(MBH)的多种强大的生物活性促使我们合成属于此类化合物的新系列产品,这些产品具有不同的功能并具有潜在的抗氧化活性。
作为我们正在进行的针对具有抗氧化活性的分子的研究计划的一部分,我们在此描述MBH醇及其衍生物(包括乙酸盐,膦酸盐和肼基膦酸盐)的不同DPPH(2,2-二苯基-1-吡啶基肼基)清除活性。所得结果表明,与其他MBH衍生物相比,在代膦酸酯的情况下观察到最强的DPPH自由基清除活性。