Background

Exposure to triclosan, an antimicrobial chemical, is ubiquitous among pregnant women and may reduce thyroid hormone levels that are important for fetal neurodevelopment. Few studies have examined the association between prenatal triclosan exposure and children's neurobehavior.

Objective

We investigated the relationship of prenatal urinary triclosan concentrations with children's behavior and cognitive abilities at age three years in a prospective pregnancy and birth cohort in Canada.

Methods

We measured triclosan in urine samples collected at ~12 weeks of gestation in 794 Canadian women enrolled in a prospective pregnancy and birth cohort study (MIREC) from 2008 to 2011. Around age 3 years, we assessed children's cognitive abilities using the Wechsler Primary and Preschool Scale of Intelligence-III (WPPSI-III), and two scales of the Behavior Rating Inventory of Executive Function-Preschool (BRIEF-P). Parents reported children's problem and reciprocal social behaviors using the Behavior Assessment System for Children-2 (BASC-2) and Social Responsiveness Scale-2 (SRS-2), respectively.

Results

After adjusting for confounders using multivariable linear regression, triclosan was not associated with most of the 30 examined neurobehavioral scales. Each 10-fold increase in triclosan was associated with better WPPSI-III picture completion scores (β: 0.2; 95% CI: 0,0.5) and BASC-2 externalizing (β: −0.5; 95% CI: −1.1, 0) and hyperactivity (β: −0.6; 95% CI: −1.2, −0.1) scores, suggesting less externalizing and hyperactive behaviors. Child sex did not modify these associations.

Conclusions

In this cohort, urinary triclosan concentrations measured once in early pregnancy were not associated with most assessed aspects of neurobehavior and weakly associated with a few others, but not in the hypothesized direction.

中文翻译：

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产前尿中三氯生浓度和儿童神经行为

背景

孕妇中普遍存在三氯生（一种抗菌化学物质）的暴露，它可能会降低对胎儿神经发育至关重要的甲状腺激素水平。很少有研究检查产前三氯生暴露与儿童神经行为之间的关系。

客观的

我们调查了加拿大预期怀孕和出生队列中三岁儿童的产前尿中三氯生浓度与儿童行为和认知能力的关系。

方法

我们测量了2008年至2011年参加一项前瞻性妊娠和出生队列研究（MIREC）的794名加拿大妇女在妊娠〜12周时收集的尿液样本中的三氯生。3岁左右，我们使用Wechsler小学和学龄前儿童评估儿童的认知能力智力-III量表（WPPSI-III）和执行功能-学前班的行为评估量表（BRIEF-P）的两个量表。父母分别使用“儿童行为评估系统2（BASC-2）”和“社会反应能力量表2（SRS-2）”报告了孩子的问题和相互的社交行为。

结果

在使用多变量线性回归调整混杂因素后，三氯生与30种检查的神经行为量表中的大多数无关。三氯生的每增加10倍与更好的WPPSI-III图片完成评分（β：0.2; 95％CI：0,0.5）和BASC-2外在化（β：-0.5; 95％CI：-1.1，0）相关联和过度活跃（β：-0.6； 95％CI：-1.2，-0.1）得分，表明较少的外部化和过度活跃行为。儿童性别并没有改变这些关联。

结论

在该队列中，妊娠早期测定一次的尿中三氯生浓度与神经行为的大多数评估方面无关，而与其他几个方面的相关程度较弱，但与假设的方向无关。