Negatively charged phosphatidylserine (PS) and sialic acid-containing glycosphingolipids (GM1) were observed to be over represented on the cell membranes of pancreatic cancer cells (BxPC-3) as opposed to normal pancreatic cells. Cationic liposomes (CL) were also found to selectively accumulate into the negatively charged cell membranes of BxPC-3 cells and inhibited their growth but have no effect on the viability of normal pancreatic cells. CL induced apoptosis in BxPC-3 cells via activation of caspase-3, -8, and -9 and mitochondrial events and inhibited tumor enlargement in xenograft mouse models of pancreatic cancer.

中文翻译：

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使用阳离子脂质体的纳米化学疗法可策略性地靶向带负电荷的胰腺癌细胞的细胞膜电位

与正常的胰腺细胞相反，在胰腺癌细胞（BxPC-3）的细胞膜上观察到带负电荷的磷脂酰丝氨酸（PS）和含唾液酸的糖鞘脂（GM1）过量表达。还发现阳离子脂质体（CL）选择性地积聚到BxPC-3细胞带负电荷的细胞膜中并抑制其生长，但对正常胰腺细胞的生存力没有影响。CL通过激活caspase-3，-8和-9和线粒体事件诱导BxPC-3细胞凋亡，并抑制胰腺癌异种移植小鼠模型中的肿瘤扩大。