Phthalates are not covalently bound to plastics. They can leach from experimental plastic devices. Due to the development of sensitive techniques, exogenous sources that interfere with the accuracy of phthalate monoester analysis can be easily detected. Here, we propose the simple and rapid dilute-and-shoot method to minimize sample handling and limit contact with laboratory apparatus, which efficiently reduced phthalate interferences mainly from experimental plasticware and improved the accuracy of analysis. Chemical additives in the mobile phase and modifiers in reconstituted solution were evaluated to improve peak shape and liquid chromatography separation. Under optimal conditions, the limit of detection ranged from 0.01 to 0.5 ng/mL. No phthalate monoesters were detected above the limit of detection in blank water while the leached concentrations of MMP, MEP, MiBP, MnBP and MEHP from the conventional solid phase extraction procedure were 1.9, 2.7, 0.9, 2.0 and 1.1 ng/mL, respectively. In 304 samples collected from primary school– children aged 9–10 years, we observed a positive association between body mass index (BMI) and urinary MMP and MiBP concentrations in boys, while MEOHP and MEHHP were inversely related to BMI in girls. Furthermore, detectable phthalate monoesters may be considered potential chemical obesogens related to BMI in children.

邻苯二甲酸酯不与塑料共价结合。他们可以从实验塑料设备中浸出。由于敏感技术的发展，很容易检测到干扰邻苯二甲酸单酯分析准确性的外源。在这里，我们提出了一种简单，快速的“稀释即拍摄”方法，以最大程度地减少样品处理并限制与实验室设备的接触，从而有效地减少了主要来自实验塑料制品的邻苯二甲酸盐的干扰，并提高了分析的准确性。对流动相中的化学添加剂和重构溶液中的改性剂进行了评估，以改善峰形和液相色谱分离。在最佳条件下，检出限为0.01至0.5 ng / mL。在空白水中，没有检测到邻苯二甲酸酯单酯的含量超过检测限，而常规固相萃取程序中浸出的MMP，MEP，MiBP，MnBP和MEHP的浓度分别为1.9、2.7、0.9、2.0和1.1 ng / mL。在从9至10岁的小学儿童中收集的304个样本中，我们观察到男孩的体重指数（BMI）与尿MMP和MiBP浓度呈正相关，而女孩的MEOHP和MEHHP与BMI呈负相关。此外，可检测的邻苯二甲酸单酯可能被认为是与儿童BMI相关的潜在化学致肥胖物。我们观察到男孩的体重指数（BMI）与尿MMP和MiBP浓度呈正相关，而女孩的MEOHP和MEHHP与BMI呈负相关。此外，可检测的邻苯二甲酸单酯可能被认为是与儿童BMI相关的潜在化学致肥胖物。我们观察到男孩的体重指数（BMI）与尿MMP和MiBP浓度呈正相关，而女孩的MEOHP和MEHHP与BMI呈负相关。此外，可检测的邻苯二甲酸单酯可能被认为是与儿童BMI相关的潜在化学致肥胖物。