Poly(ethylene glycol) methyl ether acrylate (PEGMEA) is copolymerized with 2-(ferrocenecarboxylate ethyl) methacrylate (EMA-Fc) and 4-(propoxy urethane ethyl acrylate) azobenzene (EMA-Azob), respectively. The nanoparticles can be obtained via the single-chain folding of these amphiphilic copolymers with hydrophilic poly(ethylene glycol) (PEG) side chains and hydrophobic ferrocene (or azobenzene) pendant groups in dilute aqueous solution via intramolecular hydrophobic interaction. After the addition of cyclodextrin, the inclusion complex can be formed between cyclodextrin and ferrocene (or azobenzene) pendant groups, which makes the amphiphilic copolymers hydrophilic and triggers the chain unfolding of the nanoparticles in aqueous system. Such kind of process has potential application in the fields of drug delivery systems and their controlled release, sensors, controllable catalysis, mimicry of biomacromolecules, as well as other fields.

将聚（乙二醇）甲基醚丙烯酸酯（PEGMEA）分别与2-（二茂铁羧酸乙酯）甲基丙烯酸酯（EMA-Fc）和4-（丙氧基氨基甲酸乙酯乙酯）偶氮苯（EMA-Azob）共聚。可以通过这些两亲共聚物的单链折叠，通过分子内疏水相互作用，将两亲共聚物与亲水性聚乙二醇（PEG）侧链和疏水性二茂铁（或偶氮苯）侧基基团在稀水溶液中折叠。加入环糊精后，可以在环糊精和二茂铁（或偶氮苯）侧基之间形成包合物，这使两亲共聚物具有亲水性并触发纳米粒子在水性体系中的链解链。