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Guanine-cytosine base-pairings crosslinked ROS-sensitive supramolecular hydrogels with improved rheological properties
European Polymer Journal ( IF 5.8 ) Pub Date : 2018-05-01 , DOI: 10.1016/j.eurpolymj.2018.03.004
Lin Liu , Yueting Pei , Yuandong Zhang , Jinze Wang , Li Chen

Abstract In this work, we presented a kind of intelligent supramolecular hydrogels (SHGs) based on base-pairing interaction between guanine and cytosine, comprising α-cyclodextrin, thioketals-modified guanine (G-TK-G) and cytosine-terminated PEG (C-PEG-C). The hydrogen bond of nucleic acid between G and C as an additional cross-linker effectively enhanced storage moduli (G′s) of the hydrogels. Notably, the obtained hydrogels exhibited excellent reactive oxygen species (ROS) responsive property due to the introduction of thioketals group. Under ROS-rich environment, the hydrogels could control the release of loaded-cargoes, outlining the potential of intelligent materials for biomedical application, such as smart drug delivery for anticancer.

中文翻译:

鸟嘌呤-胞嘧啶碱基配对交联 ROS 敏感的超分子水凝胶,具有改进的流变特性

摘要 在这项工作中,我们提出了一种基于鸟嘌呤和胞嘧啶碱基配对相互作用的智能超分子水凝胶 (SHGs),包括 α-环糊精、硫缩酮修饰的鸟嘌呤 (G-TK-G) 和胞嘧啶封端的 PEG (C -PEG-C)。G和C之间的核酸氢键作为额外的交联剂有效地提高了水凝胶的储能模量(G's)。值得注意的是,由于引入了硫缩酮基团,所获得的水凝胶表现出优异的活性氧(ROS)响应特性。在富含 ROS 的环境下,水凝胶可以控制负载货物的释放,概述了智能材料在生物医学应用中的潜力,例如用于抗癌的智能药物递送。
更新日期:2018-05-01
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