Copper‐Catalyzed Click Synthesis of Novel 1,2,3‐Triazole‐Linked Pyrimidines,ChemistrySelect

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Copper‐Catalyzed Click Synthesis of Novel 1,2,3‐Triazole‐Linked Pyrimidines
ChemistrySelect ( IF 1.9 ) Pub Date : 2018-03-05 , DOI: 10.1002/slct.201703088
Mohammad Bakherad ₁ , Fatemeh Rezaeimanesh ₁ , Hossein Nasr-Isfahani ₁

Affiliation

A series of novel 1,2,3‐triazole‐functionalized pyrimidines were prepared by the reaction of 4‐propargyl‐substituted‐5‐bromo‐2‐chloro‐6‐methylpyrimidine with aryl azides via copper‐catalyzed azide‐alkyne cycloaddition reactions in the presence of phenylenediamine, as a ligand. This method offers the advantages of mild experimental conditions, operational simplicity, and good to high reaction yields. Furthermore, the synthesized compounds were screened against the three bacterial strains Micrococcus luteus, Pseudomonas aeruginosa, and Bacillus subtilis.

中文翻译：

铜催化的新型1,2,3-三唑连接的嘧啶的点击合成

通过铜催化的叠氮炔-炔烃环加成反应，通过4-炔丙基取代的5-溴-2-氯-6-甲基嘧啶与芳基叠氮酸酯的反应制备了一系列新型的1,2,3-三唑官能化嘧啶。苯二胺作为配体存在。该方法具有温和的实验条件，操作简便以及反应产率高至高的优点。此外，针对三种细菌菌株：黄褐微球菌，铜绿假单胞菌和枯草芽孢杆菌，筛选了合成的化合物。

更新日期：2018-03-05

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