Gene therapy with small interfering RNA (siRNA) has been proved to be a promising technology to treat various diseases by hampering the production of target proteins. However, developing a delivery system that has high efficiency in transporting siRNA without obvious side effects remains a challenge. Herein, we designed a new survivin siRNA delivery system based on polyethyleneimine functionalized black phosphorus (BP) nanosheets which could suppress tumor growth by silencing survivin expression. Combined with the photothermal properties of the BP nanosheets, the presented delivery system shows excellent therapy efficiency for tumors. Therefore, the BP-based delivery system would be a promising tool for future clinical applications.

中文翻译：

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基于黑磷纳米片的siRNA递送系统，用于协同光热和基因治疗†

小干扰RNA（siRNA）的基因疗法已被证明是通过阻止靶蛋白的产生来治疗各种疾病的有前途的技术。然而，开发在没有明显副作用的情况下高效运输siRNA的递送系统仍然是一个挑战。本文中，我们基于聚乙烯亚胺官能化的黑磷（BP）纳米片设计了一种新的survivin siRNA递送系统，该系统可通过沉默survivin表达来抑制肿瘤的生长。结合BP纳米片的光热特性，提出的递送系统显示出优异的肿瘤治疗效率。因此，基于BP的输送系统将是未来临床应用的有前途的工具。