Summary: Autophagy has been identified as a potential therapeutic target in pancreatic ductal adenocarcinoma, one of the most lethal cancers, with few therapeutic options. Yang and colleagues successfully created a genetically engineered mouse model focused on the autophagy gene Atg4b that allows the study of therapeutic autophagy inhibition in fully formed tumors. Using this tool, they demonstrated that selective autophagy inhibition in either the tumor cells, normal host cells, or both suppresses tumor growth. Cancer Discov; 8(3); 266–8. ©2018 AACR

See related article by Yang et al., p. 276.

中文翻译：

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自体吞噬在肿瘤或宿主中：哪种起着更大的辅助作用？

摘要：自噬已被确定为胰腺导管腺癌的潜在治疗靶点，这是最致命的癌症之一，几乎没有治疗选择。Yang和他的同事成功地创建了一个基因工程小鼠模型，该模型专注于自噬基因Atg4b，该模型可以研究完全形成的肿瘤中治疗性自噬的抑制作用。他们证明了使用该工具在肿瘤细胞，正常宿主细胞或两者中的选择性自噬抑制作用可抑制肿瘤的生长。巨蟹座Discov; 8（3）；266-8。©2018 AACR

参见Yang等人的相关文章，第3页。276。