Biodegradable Inverse Opals with Controlled Discoloration,Advanced Materials Interfaces

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Biodegradable Inverse Opals with Controlled Discoloration
Advanced Materials Interfaces ( IF 4.3 ) Pub Date : 2018-03-02 , DOI: 10.1002/admi.201701658
Ji-Won Kim ₁ , Joon-Seok Lee ₁ , Shin-Hyun Kim ₁

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Colloidal crystals and their derivatives possess photonic bandgap property, being useful in various applications, including structural coloration and colorimetric sensing. In this work, inverse opals made of a biodegradable polymer, poly(lactic‐co‐glycolic acid) (PLGA), are prepared to provide a controlled discoloration. To make PLGA inverse opals, a monolayer of silica particles is first deposited on the surface of PLGA film by spin coating, which is then partially embedded into the film by thermal annealing. Opal is deposited on the monolayer‐coated PLGA film by dip coating and then embedded into the underlying PLGA film. Selective removal of silica particles leaves behind a face‐centered cubic lattice of air cavity in PLGA matrix. The inverse opals whose framework is made of PLGA exhibit a pronounced structural color in dried state. When they are subjected to water, PLGA degrades by hydrolysis of ester groups, which results in the gradual discoloration. The discoloration rate is controllable by varying the pH of surrounding medium and cavity sizes, so that it can act as a colorimetric indicator of valid periods for drugs, foods, and cosmetics. In addition, high biocompatibility and unique optical appearance further render the inverse opals useful as edible anticounterfeiting materials for valuable drugs.

中文翻译：

可控制变色的生物可降解反蛋白石

胶体晶体及其衍生物具有光子带隙特性，可用于各种应用中，包括结构着色和比色传感。在这项工作中，反蛋白石制成的可生物降解的聚合物，聚（乳酸-的共-乙醇酸（PLGA），可提供受控的变色效果。为了使PLGA反蛋白石，首先通过旋涂将二氧化硅颗粒单层沉积在PLGA膜的表面，然后通过热退火将其部分嵌入膜中。蛋白石通过浸涂法沉积在单层涂层的PLGA膜上，然后嵌入到下面的PLGA膜中。选择性去除二氧化硅颗粒会在PLGA矩阵中留下以面心为中心的气腔立方晶格。框架由PLGA制成的反蛋白石在干燥状态下表现出明显的结构颜色。当它们遇水时，PLGA通过酯基的水解而降解，从而导致逐渐变色。变色速率可通过改变周围介质的pH值和空腔大小来控制，因此它可以用作药物，食品和化妆品有效期的比色指示剂。此外，高生物相容性和独特的光学外观进一步使反蛋白石可用作有价值的药物的食用防伪材料。

更新日期：2018-03-02

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