Ruthenium‐Catalyzed Cascade Annulation of Indole with Propargyl Alcohols,Angewandte Chemie International Edition

当前位置： X-MOL 学术 › Angew. Chem. Int. Ed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Ruthenium‐Catalyzed Cascade Annulation of Indole with Propargyl Alcohols
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-04-16 , DOI: 10.1002/anie.201801846
Julia Kaufmann ₁ , Elisabeth Jäckel ₁ , Edgar Haak ₁

Affiliation

Cascade transformations forming multiple bonds and one‐pot procedures provide rapid access to natural‐product‐like scaffolds from simple precursors. These atom‐economic processes are valuable tools in organic synthesis and drug discovery. Herein, we report on ruthenium‐catalyzed cascade annulations of indole with readily available propargyl alcohols. These provide rapid access to diverse carbazoles, cyclohepta[b]indoles, and further fused polycycles with high selectivity. A bifunctional ruthenium complex featuring a redox‐coupled cyclopentadienone ligand acts as a common catalyst for the different cascade processes.

中文翻译：

钌催化的炔丙基醇与级联的吲哚

形成多个键和一锅法的级联转化提供了从简单前体中快速获得天然产物样支架的途径。这些原子经济过程是有机合成和药物发现中的宝贵工具。本文中，我们报道了钌与容易获得的炔丙醇的级联环空反应。这些提供了快速接近各种咔唑，环庚[ b ]吲哚和其他具有高选择性的稠合多环的途径。具有氧化还原偶联的环戊二烯酮配体的双功能钌配合物可作为不同级联过程的常用催化剂。

更新日期：2018-04-16

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11