Point‐of‐Care Identification of Bacteria Using Protein‐Encapsulated Gold Nanoclusters,Advanced Healthcare Materials

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Point‐of‐Care Identification of Bacteria Using Protein‐Encapsulated Gold Nanoclusters
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-03-02 , DOI: 10.1002/adhm.201701370
Haiwei Ji _{1,

2} , Li Wu _{1,

3} , Fang Pu ₁ , Jinsong Ren ₁ , Xiaogang Qu ₁

Affiliation

The rapid, simple, and reliable identification of the most prevalent pathogens is essential for clinical diagnostics, biology, and food safety. Herein, four protein‐encapsulated gold nanoclusters (protein–AuNCs) are designed and prepared as a sensor array for rapid identification of bacteria. The discrimination of six kinds of bacteria, including two kinds of drug‐resistant bacteria, is successfully realized by the as‐fabricated sensor array. The strategy presented here shows the advantages of easy synthesis and convenient to use. Furthermore, 100% classification accuracy is achieved by the sensor array consisting of two protein–AuNCs probes, demonstrating the design with sufficient diagnostic capacity. Taken together, the developed sensor array holds great promise for facile diagnosis of bacterial infection in resource‐limited settings.

中文翻译：

使用蛋白质包裹的金纳米簇对细菌进行现场护理鉴定

快速，简单和可靠地识别最流行的病原体对于临床诊断，生物学和食品安全至关重要。在此，设计并制备了四个蛋白质包裹的金纳米簇（蛋白质-AuNCs）作为用于快速鉴定细菌的传感器阵列。预制的传感器阵列成功实现了对六种细菌的区分，其中包括两种耐药菌。此处介绍的策略显示了易于合成且易于使用的优点。此外，由两个蛋白质AuNCs探针组成的传感器阵列可实现100％的分类精度，从而证明了该设计具有足够的诊断能力。综上所述，开发的传感器阵列有望在资源有限的环境中轻松诊断细菌感染。

更新日期：2018-03-02

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