Although nanomaterial‐mediated phototherapy, in particular photothermal therapy (PTT) and photodynamic therapy (PDT), is extensively investigated in recent years, the ablation mechanism, evolution, and rehabilitation process of in vivo solid tumor after phototherapy are rarely explored yet and remain a terra incognita. Herein, a kind of bismuth ferrite nanoparticles (abbreviated as BFO NPs) are strategically designed and synthesized with a desirable size and bioactivity as a brand‐new phototherapeutic agent for the phototherapy, which are of strong near infrared (NIR) absorbance, excellent biocompatibility, and outstanding photophysical activity for the hyperthemia and reactive oxygen species generation. Resultantly, BFO NPs can realize simultaneous PTT/PDT synergistic therapy outcome against cancer cells and solid tumor under NIR laser irradiation. Meanwhile, for the first time, more attentions are paid to demonstrate ablation mechanism and evolution process of in vivo solid tumor after phototherapy by B‐mode ultrasonography/magnetic resonance imaging as well as histopathological analysis, all of which verify a series of physiological processes, being in order of necrosis of parenchymal cells, in situ tissue disintegration, liquefaction, and finally encapsulation process.

中文翻译：

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基于铋铁氧体的纳米平台设计：实体瘤和近红外触发光热/光动力联合癌症治疗的消融机制研究

尽管近年来对纳米材料介导的光疗，特别是光热疗法（PTT）和光动力疗法（PDT）进行了广泛的研究，但光疗后体内实体瘤的消融机制，演变和康复过程仍很少被探索，并且仍然是一个主要问题。兵马俑 在此，战略性地设计和合成了一种具有理想尺寸和生物活性的铋铁氧体纳米粒子（缩写为BFO NPs），作为一种全新的光疗光疗剂，具有强的近红外（NIR）吸收率，出色的生物相容性，和出色的光物理活性，可用于充血和产生活性氧。结果，BFO NP可以在NIR激光照射下同时实现针对癌细胞和实体瘤的PTT / PDT协同治疗效果。同时，首次通过B型超声/磁共振成像以及组织病理学分析证明了光疗后体内实体瘤的消融机制和演变过程，所有这些都证实了一系列生理过程，按照实质细胞坏死的顺序，原位组织崩解，液化，最后是包囊过程。