Bone regeneration is a complicated physiological process comprising of bone formation and resorption under the circumstances of some pathological conditions. This review highlights the recent development of self-assembled supramolecular systems, including spontaneous collagen-based scaffold, self-assembled peptide-based materials, modified cyclodextrin-based materials, and assembled protein or viral particles in bone regeneration applications. These self-assembled structures can offer two unique advantages for bone tissue engineering: (1) through rational design, highly ordered self-assembled supramolecular structures can be produced to display multiple functional units in a polyvalent manner; and (2) the reversible assembly-disassembly process renders the supramolecular assembly the responsiveness towards environmental or cellular stimuli. Thus, we envision that the self-assembled supramolecular materials provide promising options in clinical bone regeneration applications.

骨再生是一个复杂的生理过程，包括在某些病理情况下的骨形成和吸收。这篇综述强调了自组装超分子系统的最新发展，包括自发的基于胶原的支架，自组装的基于肽的材料，改性的环糊精为基础的材料以及在骨再生应用中组装的蛋白质或病毒颗粒。这些自组装结构可以为骨组织工程提供两个独特的优势：（1）通过合理的设计，可以生产出高度有序的自组装超分子结构，以多价方式展示多个功能单元；（2）可逆的组装-拆卸过程使超分子组装对环境或细胞刺激具有响应性。因此，