Non-communicable diseases including cancer, cardiovascular disease, diabetes, and neuropathy are chronic in nature. Treatment of these diseases with traditional delivery systems is limited due to lack of site-specificity, non-spatiotemporal release and insufficient doses. Numerous responsive delivery systems which respond to both physiological and external stimuli have been reported in the literature. However, effective strategies incorporating a multifactorial approach are required to control these complex wounds. This can be achieved by fabricating spatiotemporal release systems, multimodal systems or dual/multi-stimuli responsive delivery systems loaded with one or more bioactive components. Critically, these next generation stimuli responsive delivery systems that are at present not feasible are required to treat chronic wounds. This review provides a critical assessment of recent developments in the field of responsive delivery systems, highlighting their limitations and providing a perspective on how these challenges can be overcome.

包括癌症，心血管疾病，糖尿病和神经病在内的非传染性疾病本质上是慢性的。由于缺乏位点特异性，非时空释放和剂量不足，传统的传递系统对这些疾病的治疗受到限制。在文献中已经报道了许多响应生理和外部刺激的响应性递送系统。但是，需要有效的策略结合多因素方法来控制这些复杂的伤口。这可以通过制造时空释放系统，多峰系统或加载有一种或多种生物活性成分的双/多刺激响应性递送系统来实现。至关重要的是，需要这些目前尚不可行的下一代刺激响应性递送系统来治疗慢性伤口。