N-acetyltransferase-2 (NAT2) and Glutathione S-transferases (GSTs) are phase-II xenobiotic metabolizing enzymes participating in detoxification of toxic arylamines, aromatic amines, hydrazines and reactive oxygen species (ROS), which are produced under oxidative and electrophile stresses. The purpose of this research was to investigate whether two common single-nucleotide polymorphisms (SNP) of NAT2 (rs1799929, rs1799930) and GSTP1 (rs1138272, rs1695) associated with susceptibility to idiopathic male infertility. A total 300 DNA samples (150 infertile patients and 150 healthy control) were genotyped for the polymorphisms by ARMS - PCR. We revealed a significant association between the NAT2 variant genotypes (CT + TT (rs1799929), (OR: 3.74; p < 0.001)) and (GA + AA (rs1799930), (OR: 3.75; p < 0.001)) or GSTP1 variant genotypes (GA + AA (rs1695), (OR: 5.11; p < 0,001)) and (CT + TT (rs1138272), (OR: 7.42; p < 0,001) with idiopathic infertility risk. Our findings rate the effect of single-nucleotide polymorphisms of GSTP1 and/or NAT2 in modulation of the risk of male infertility in subjects from Vietnam. This pilot study is the first (as far as we know) to reveal that polymorphisms of NAT2 (rs1799929, rs1799930) and GSTP1 (rs1138272, rs1695) are some novel genetic markers for susceptibility to idiopathic male infertility.

N-乙酰基转移酶2（NAT2）和谷胱甘肽S-转移酶（GST）是II期异源生物代谢酶，参与有毒芳基胺，芳族胺，肼和活性氧（ROS）的解毒，它们在氧化和亲电胁迫下产生。这项研究的目的是调查NAT2（rs1799929，rs1799930）和GSTP1（rs1138272，rs1695）的两种常见单核苷酸多态性（SNP）是否与特发性男性不育症的易感性相关。通过ARMS-PCR对300份DNA样本（150例不育患者和150例健康对照）进行了多态性基因分型。我们发现NAT2变异基因型（CT + TT（rs1799929），（OR：3.74; p <0.001））和（GA + AA（rs1799930），（OR：3.75; p <0）之间存在显着关联。