Background

Survival data are mixed comparing patients with multiple primary melanomas (MPM) to those with single primary melanomas (SPM).

Objectives

We compared MPM versus SPM patient survival using a matching method that avoids potential biases associated with other analytic approaches.

Methods

Records of 14,138 individuals obtained from the Surveillance, Epidemiology, and End Results registry of all melanomas diagnosed or treated in Utah between 1973 and 2011 were reviewed. A single matched control patient was selected randomly from the SPM cohort for each MPM patient, with the restriction that they survived at least as long as the interval between the first and second diagnoses for the matched MPM patient.

Results

Survival curves (n = 887 for both MPM and SPM groups) without covariates showed a significant survival disadvantage for MPM patients (chi-squared 39.29, P < .001). However, a multivariate Cox proportional hazards model showed no significant survival difference (hazard ratio 1.07, P = .55). Restricting the multivariate analysis to invasive melanomas also showed no significant survival difference (hazard ratio 0.99, P = .96).

Limitations

Breslow depth, ulceration status, and specific cause of death were not available for all patients.

Conclusions

Patients with MPM had similar survival times as patients with SPM.

中文翻译：

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根据犹他州监测、流行病学和最终结果数据（1973-2011 年），多发性原发性黑色素瘤患者与单发性原发性黑色素瘤患者的生存率相似

 背景

比较多原发性黑色素瘤 (MPM) 患者与单原发性黑色素瘤 (SPM) 患者的生存数据混杂。

 目标

我们使用匹配方法比较了 MPM 与 SPM 患者的生存率，该方法避免了与其他分析方法相关的潜在偏差。

 方法

对从 1973 年至 2011 年间在犹他州诊断或治疗的所有黑色素瘤的监测、流行病学和最终结果登记处获得的 14,138 名个体的记录进行了审查。从每个 MPM 患者的 SPM 队列中随机选择一个匹配的对照患者，限制条件是他们的存活时间至少与匹配的 MPM 患者的第一次和第二次诊断之间的间隔一样长。

 结果

无协变量的生存曲线（MPM 和 SPM 组 n = 887）显示 MPM 患者存在显着的生存劣势（卡方 39.29， P < .001）。然而，多变量 Cox 比例风险模型显示没有显着的生存差异（风险比 1.07， P = 0.55）。将多变量分析限制于侵袭性黑色素瘤也显示没有显着的生存差异（风险比 0.99， P = .96）。

 局限性

并非所有患者都可获得 Breslow 深度、溃疡状态和具体死亡原因。

 结论

MPM 患者与 SPM 患者的生存时间相似。