The resistance of Bacteroides fragilis to the most antimicrobial agents has been reported in the world. Identification of the microbial resistance mechanisms can play an important role in controlling these resistances. Currently, B. fragilis is resistant to most antibiotics. The multi-drug efflux pumps have been shown to underlie the antimicrobial resistance in B. fragilis strains. Two types of these efflux pumps including RND and MATE can be regarded as main structures responsible for antibiotic resistance. Therefore, the strategy for suppressing of this efflux system may be useful in the treatment and control of the multidrug-resistant B. fragilis. The purpose of this study is to review the B. fragilis efflux pumps and their functions in the resistance to antibiotics.

全世界已经报道了脆弱的拟杆菌对大多数抗菌剂的抗性。微生物抗性机制的鉴定可以在控制这些抗性中发挥重要作用。目前，脆弱的芽孢杆菌对大多数抗生素具有抗性。多种药物外排泵已被证明是脆弱脆弱芽孢杆菌菌株的抗药性的基础。这些外排泵中的两种类型，包括RND和MATE，可以被视为负责抗生素耐药性的主要结构。因此，抑制这种外排系统的策略可能在治疗和控制耐多药脆弱性芽孢杆菌中有用。这项研究的目的是审查脆弱的芽孢杆菌 外排泵及其对抗生素的抗药性。