Novel neuroprotective therapies are desperately needed to improve neuronal recovery after ischemic stroke and extend the therapeutic window or offset some of the adverse effects of tissue-type plasminogen activator (tPA). These advances could provide a more effective and safe therapeutic regimen for patients with ischemic stroke. The opioid system has gained intense interest over the past few years and is currently being investigated as a viable target for the pharmacological treatment of stroke. In this review, we focus on different opioid receptors (ORs) and their distribution in the central nervous system (CNS), and the effect of ischemic stroke on their redistribution. We also discuss studies involving the use of the selective and nonselective and/or simultaneous targeting of ORs for neuroprotection during ischemic stroke.

迫切需要新的神经保护疗法，以改善缺血性中风后的神经元恢复并扩大治疗范围或抵消组织型纤溶酶原激活剂（tPA）的某些不利影响。这些进展可以为缺血性中风患者提供更有效和安全的治疗方案。在过去的几年中，阿片类药物系统引起了广泛的兴趣，目前正在作为中风药理学治疗的可行目标进行研究。在这篇综述中，我们关注于不同的阿片受体（OR）及其在中枢神经系统（CNS）中的分布，以及缺血性中风对其重新分布的影响。我们还将讨论涉及在缺血性卒中过程中使用选择性和非选择性和/或同时靶向ORs进行神经保护的研究。