Background & Aims

There have been many studies of associations between infant feeding practices and development of celiac disease during childhood, but few studies have focused on overall diets of young children after the weaning period. We aimed to examine the association between common dietary patterns in infants and the occurrence of celiac disease autoimmunity during childhood.

Methods

We performed a prospective analysis of data from the Generation R Study that comprised 1997 children born from April 2002 through January 2006 in Rotterdam, the Netherlands. Food consumption around 1 year of age was assessed with a validated food-frequency questionnaire. Dietary data were examined using a priori (based on existing guidelines) and a posteriori (principal component analysis and reduced rank regression) dietary pattern analyses. Five dietary patterns were compared. Celiac disease autoimmunity, determined on the basis of serum concentration of transglutaminase-2 autoantibody (ie, TG2A) below or above 7 U/mL, was evaluated at 6 years. Associations between dietary pattern adherence scores and celiac disease autoimmunity were examined using multivariable logistic regression models.

Results

Higher adherence to the a posteriori–derived prudent dietary pattern (high intake of vegetables, vegetable oils, pasta, and grains and low consumption of refined cereals and sweet beverages) at 1 year was significantly associated with lower odds of celiac disease autoimmunity at 6 years (odds ratio, 0.67; 95% confidence interval, 0.53–0.84). No significant associations were found for the 4 remaining dietary patterns.

Conclusions

In a prospective study of dietary patterns of young children in the Netherlands, we associated a dietary pattern characterized by high consumption of vegetables and grains and low consumption of refined cereals and sweet beverages, with lower odds of celiac disease autoimmunity. Early-life dietary patterns might therefore be involved in the development of celiac disease during childhood.

中文翻译：

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断奶和哺乳期后的饮食习惯与儿童乳糜泻自身免疫相关

背景与目标

关于婴儿喂养方式与童年时期腹腔疾病的发展之间的关联有许多研究，但很少有研究集中在断奶期后幼儿的整体饮食上。我们的目的是检查婴儿常见的饮食习惯与童年时期腹腔疾病自身免疫的发生之间的关系。

方法

我们对R代研究的数据进行了前瞻性分析，该研究包括2002年4月至2006年1月在荷兰鹿特丹出生的1997名儿童。用经过验证的食物频率调查表评估1岁左右的食物消费量。使用先验（基于现有指南）和后验（主要成分分析和降级回归）饮食模式分析来检查饮食数据。比较了五种饮食方式。在6年时，根据低于或高于7 U / mL的转谷氨酰胺酶2自身抗体（即TG2A）的血清浓度确定的腹腔疾病自身免疫性。饮食模式依从性评分与腹腔疾病自身免疫之间的关联使用多变量logistic回归模型进行了检验。

结果

在1年时较高地遵循后验的审慎饮食模式（大量摄入蔬菜，植物油，意大利面和谷物，而少食用精制谷物和甜饮料）与6年时腹腔疾病自身免疫的机率降低相关（赔率，0.67； 95％置信区间，0.53-0.84）。其余4种饮食模式均未发现明显关联。

结论

在一项对荷兰幼儿饮食模式的前瞻性研究中，我们关联了一种饮食模式，其特点是大量食用蔬菜和谷物，而少食用精制谷物和甜饮料，而腹腔疾病自身免疫的几率较低。因此，儿童时期早期的饮食习惯可能与乳糜泻的发展有关。