A large amount of food-grade animal by-products is annually produced during industrial processing and they are normally utilized as animal feed or other low-value purposes. These by-products are good sources of valuable proteins, including collagen or gelatin. The revalorization of collagen may lead to development of a high benefit-to-cost ratio. In this review, the major approaches for generation of collagen peptides with a wide variety of bioactivities were summarized, including antihypertensive, antioxidant and antidiabetic activities, and beneficial effects on bone, joint and skin health. The biological potentials of collagen peptides and their bioavailability were reviewed. Moreover, the unique advantages of collagen peptides over other therapeutic peptides were highlighted. In addition, the current challenges for development of collagen peptides as functional food ingredients were also discussed. This article discusses the opportunity to utilize collagen peptides as high value-added bio-functional ingredients in the food industry.

中文翻译：

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从动物副产品中回收的胶原蛋白作为生物活性肽的前体的探索：成功与挑战

在工业加工过程中，每年会生产大量食品级动物副产品，它们通常用作动物饲料或其他低价值用途。这些副产物是有价值的蛋白质（包括胶原蛋白或明胶）的良好来源。胶原蛋白的重新定价可能导致发展高的成本效益比。在这篇综述中，总结了产生具有多种生物活性的胶原蛋白肽的主要方法，包括抗高血压，抗氧化和抗糖尿病活性，以及​​对骨骼，关节和皮肤健康的有益作用。胶原肽的生物潜力及其生物利用度进行了审查。此外，突出了胶原蛋白肽相对于其他治疗性肽的独特优势。此外，还讨论了开发胶原蛋白肽作为功能性食品成分的当前挑战。本文讨论了在食品工业中利用胶原蛋白肽作为高附加值生物功能成分的机会。