Wound healing, a complex physiological process, is responsible for tissue repair after exposure to destructive stimuli, without resulting in complete functional regeneration. Injuries can be stromal or epithelial, and most cases of wound repair have been studied in the skin and cornea. Lumican, a small leucine-rich proteoglycan, is expressed in the extracellular matrices of several tissues, such as the cornea, cartilage, and skin. This molecule has been shown to regulate collagen fibrillogenesis, keratinocyte phenotypes, and corneal transparency modulation. Lumican is also involved in the extravasation of inflammatory cells and angiogenesis, which are both critical in stromal wound healing. Lumican is the only member of the small leucine-rich proteoglycan family expressed by the epithelia during wound healing.

This review summarizes the importance of lumican in wound healing and potential methods of lumican drug delivery to target wound repair are discussed. The involvement of lumican in corneal wound healing is described based on in vitro and in vivo models, with critical emphasis on its underlying mechanisms of action. Similarly, the expression and role of lumican in the healing of other tissues are presented, with emphasis on skin wound healing.

Overall, lumican promotes normal wound repair and broadens new therapeutic perspectives for impaired wound healing.

伤口愈合是一个复杂的生理过程，暴露于破坏性刺激后可负责组织修复，而不会导致完全的功能再生。损伤可能是间质或上皮损伤，大多数伤口修复病例已在皮肤和角膜上进行了研究。Lumican是一种富含亮氨酸的小蛋白聚糖，在几种组织（例如角膜，软骨和皮肤）的细胞外基质中表达。已显示该分子调节胶原纤维形成，角质形成细胞表型和角膜透明性调节。Lumican还参与炎症细胞的渗出和血管生成，这两者在基质伤口愈合中都至关重要。Lumican是伤口愈合期间上皮细胞表达的富含亮氨酸的小蛋白聚糖家族的唯一成员。

这篇综述总结了卢米肯在伤口愈合中的重要性，并讨论了将卢米肯药物递送至目标伤口修复的潜在方法。基于体外和体内模型描述了卢米肯在角膜伤口愈合中的作用，并着重强调了其潜在的作用机理。类似地，呈现了卢米肯胶在其他组织愈合中的表达和作用，并着重于皮肤伤口的愈合。

总体而言，lumican可促进正常的伤口修复，并为受损的伤口愈合开辟新的治疗方法。