Pharmacogenetics and pharmacogenomics focus on identification of genetic markers associated with response to, or side-effects of, a particular medication. Unlike genetic studies of susceptibility to complex diseases, including psychiatric disorders, in which very small individual effect sizes are assumed, in pharmacogenetics and pharmacogenomics the effect size of genetic markers is assumed to be larger (eg, odds ratios of roughly >5–10), facilitating the detection of significant associations in studies with smaller sample sizes.

中文翻译：

---

精神分裂症抗精神病反应的遗传学

药物遗传学和药物基因组学的重点是鉴定与对特定药物的反应或副作用相关的遗传标记。与对包括精神疾病在内的复杂疾病的易感性进行的遗传学研究不同，在这种研究中，假定个体效应很小，在药物遗传学和药物基因组学中，遗传标记物的效应大小被认为较大（例如，比值比大约> 5-10） ，有助于在样本量较小的研究中发现重要的关联。