Exploring Strategies To Bias Sequence in Natural and Synthetic Oligomers and Polymers,Accounts of Chemical Research

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Exploring Strategies To Bias Sequence in Natural and Synthetic Oligomers and Polymers
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2018-03-01 00:00:00 , DOI: 10.1021/acs.accounts.7b00495
Jan K. Szymański ₁ , Yousef M. Abul-Haija ₁ , Leroy Cronin ₁

Affiliation

Millions of years of biological evolution have driven the development of highly sophisticated molecular machinery found within living systems. These systems produce polymers such as proteins and nucleic acids with incredible fidelity and function. In nature, the precise molecular sequence is the factor that determines the function of these macromolecules. Given that the ability to precisely define sequence emerges naturally, the fact that biology achieves unprecedented control over the unit sequence of the monomers through evolved enzymatic catalysis is incredible. Indeed, the ability to engineer systems that allow polymer synthesis with precise sequence control is a feat that technology is yet to replicate in artificial synthetic systems. This is the case because, without access to evolutionary control for finely tuned biological catalysts, the inability to correct errors or harness multiple competing processes means that the prospects for digital control of polymerization have been firmly bootstrapped to biological systems or limited to stepwise synthetic protocols.

中文翻译：

天然和合成低聚物和聚合物中偏倚序列的探索策略

数百万年的生物进化推动了生命系统中发现的高度复杂的分子机械的发展。这些系统产生具有令人难以置信的保真度和功能的聚合物，例如蛋白质和核酸。实际上，精确的分子序列是决定这些大分子功能的因素。鉴于自然会出现精确定义序列的能力，生物学通过进化的酶催化实现对单体单元序列的空前控制是不可思议的事实。确实，能够通过精确的序列控制来设计允许聚合物合成的系统的能力是一项技术尚未在人造合成系统中复制的壮举。出现这种情况是因为，如果无法对精细调整的生物催化剂进行进化控制，

更新日期：2018-03-01

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