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Fabrication of Hexagonal-Prismatic Granular Hydrogel Sheets
Langmuir ( IF 3.7 ) Pub Date : 2018-02-28 00:00:00 , DOI: 10.1021/acs.langmuir.7b04163
Huachuan Du 1 , Alice Cont 1 , Mathias Steinacher 1 , Esther Amstad 1
Affiliation  

Natural soft materials are often composed of proteins that self-assemble into well-defined structures and display mechanical properties that cannot be matched by manmade materials. These materials are frequently mimicked with hydrogels whose mechanical properties depend on their composition and the type and density of cross-links. Protocols to tune these parameters are well established and routinely used. The mechanical properties of hydrogels also depend on their structure; this parameter is more difficult to control. In this paper, we present a method to produce hexagonal-prismatic granular hydrogel sheets with well-defined structures and heterogeneous cross-link densities. The hydrogel sheets are made of self-assembled covalently cross-linked 40–120 μm diameter hexagonal-prismatic hydrogel particles that display a narrow size distribution. The structure and microscale surface roughness of the hydrogels sheets can be tuned with the polymerization conditions, their chemical composition with that of the individual hydrogel particles, and their mechanical properties with the cross-link density. Remarkably, the hydrogels composed of hexagonal-prismatic microparticles are significantly stiffer than unstructured counterparts. These results demonstrate that the stiffness of hydrogels can be tuned by controlling their micrometer-scale structure without altering their composition. Thereby, they open up new possibilities to design soft materials whose performance more closely resembles that of natural ones.

中文翻译:

六角棱柱形颗粒水凝胶片的制备

天然软材料通常由蛋白质组成,这些蛋白质会自组装成定义明确的结构,并显示出人造材料无法匹敌的机械性能。这些材料经常被水凝胶模仿,其机械性能取决于其组成以及交联的类型和密度。调整这些参数的协议已经很好地建立并被常规使用。水凝胶的机械性能还取决于其结构。此参数更难控制。在本文中,我们提出了一种生产具有明确结构和异质交联密度的六角棱柱形颗粒水凝胶片的方法。水凝胶片材是由自组装的共价交联的直径为40-120μm的六角棱柱形水凝胶颗粒制成,其粒径分布较窄。水凝胶片的结构和微观表面粗糙度可以根据聚合条件,其化学组成与各个水凝胶颗粒的化学组成以及其机械性能与交联密度进行调节。值得注意的是,由六方棱柱形微粒组成的水凝胶比未结构化的对应物坚硬得多。这些结果表明,可以通过控制水凝胶的微米级结构而不改变其组成来调节水凝胶的刚度。因此,它们为设计性能更接近天然材料的软材料开辟了新的可能性。以及它们的机械性能与交联密度。值得注意的是,由六方棱柱形微粒组成的水凝胶比未结构化的对应物坚硬得多。这些结果表明,可以通过控制水凝胶的微米级结构而不改变其组成来调节水凝胶的刚度。因此,它们为设计性能更接近天然材料的软材料开辟了新的可能性。以及它们的机械性能与交联密度。值得注意的是,由六方棱柱形微粒组成的水凝胶比未结构化的对应物坚硬得多。这些结果表明,可以通过控制水凝胶的微米级结构而不改变其组成来调节水凝胶的刚度。因此,它们为设计性能更接近自然材料的软材料开辟了新的可能性。
更新日期:2018-02-28
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