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Near Infrared Light Sensitive Ultraviolet–Blue Nanophotoswitch for Imaging-Guided “Off–On” Therapy
ACS Nano ( IF 15.8 ) Pub Date : 2018-02-28 00:00:00 , DOI: 10.1021/acsnano.7b07393 Jing Zuo 1, 2 , Langping Tu 1 , Qiqing Li 1 , Yansong Feng 2 , Ivo Que 3 , Youlin Zhang 1 , Xiaomin Liu 1 , Bin Xue 1 , Luis J. Cruz 3 , Yulei Chang 1 , Hong Zhang 2 , Xianggui Kong 1
ACS Nano ( IF 15.8 ) Pub Date : 2018-02-28 00:00:00 , DOI: 10.1021/acsnano.7b07393 Jing Zuo 1, 2 , Langping Tu 1 , Qiqing Li 1 , Yansong Feng 2 , Ivo Que 3 , Youlin Zhang 1 , Xiaomin Liu 1 , Bin Xue 1 , Luis J. Cruz 3 , Yulei Chang 1 , Hong Zhang 2 , Xianggui Kong 1
Affiliation
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Photoswitchable materials are important in broad applications. Recently appeared inorganic photoswitchable upconversion nanoparticles (PUCNPs) become a competitive candidate to surmount the widespread issue of the organic counterparts —photobleaching. However, current PUCNPs follow solely Yb3+/Nd3+ cosensitizing mode, which results in complex multilayer doping patterns and imperfectness of switching in UV–blue region. In this work, we have adopted a new strategy to construct Nd3+ free PUCNPs—NaErF4@NaYF4@NaYbF4:0.5%[email protected]4. These PUCNPs demonstrate the superior property of photoswitching. A prominent UV–blue emission from Tm3+ is turned on upon 980 nm excitation, which can be completely turned off by 800 nm light. The quasi-monochromatic red upconversion emission upon 800 nm excitation—a distinct feature of undoping NaErF4 upconversion system—endows the PUCNPs with promising image-guided photoinduced “off–on” therapy in biomedicine. As a proof-of-concept we have demonstrated the imaging-guided photodynamic therapy (PDT) of cancer, where 800 nm excitation turns off the UV–blue emission and leaves the emission at 660 nm for imaging. Once the tumor site is targeted, excitation switching to 980 nm results in UV–blue emission and the red emission. The former is used to induce PDT, whereas the latter is to monitor the therapeutic process. Our study implies that this upconversion photoswitching material is suitable for real-time imaging and image-guided therapy under temporal and spatial control.
中文翻译：
近红外光敏紫外-蓝色纳米光电开关，用于影像引导下的“开-关”疗法
光开关材料在广泛的应用中很重要。最近出现的无机光开关上转换纳米粒子（PUCNPs）成为竞争者，可以克服有机对等物的广泛问题-光漂白。但是，当前的PUCNP仅遵循Yb 3+ / Nd 3+共敏化模式，这会导致复杂的多层掺杂模式以及在UV-蓝色区域中切换的不完善性。在这项工作中，我们采用了一种新的策略来构建Nd 3+的免费PUCNPs-NaErF 4 @NaYF 4 @NaYbF 4：0.5％[电子邮件保护] 4。这些PUCNP证明了光电开关的优越性能。Tm 3+产生明显的紫外-蓝色辐射在980 nm的激发下开启，可以被800 nm的光完全关闭。800 nm激发下的准单色红色上转换发射-未掺杂NaErF 4的显着特征上转换系统-为PUCNP提供了有前途的图像指导的生物医学光诱导“关闭”疗法。作为概念验证，我们已经证明了癌症的成像指导光动力疗法（PDT），其中800 nm的激发会关闭UV-蓝色发射，而将发射保持在660 nm进行成像。一旦确定了肿瘤部位，激发切换到980 nm会导致UV蓝光发射和红光发射。前者用于诱导PDT，而后者则用于监测治疗过程。我们的研究表明，这种上转换光开关材料适用于时空控制下的实时成像和图像指导治疗。
更新日期：2018-02-28
中文翻译：
近红外光敏紫外-蓝色纳米光电开关，用于影像引导下的“开-关”疗法
光开关材料在广泛的应用中很重要。最近出现的无机光开关上转换纳米粒子（PUCNPs）成为竞争者，可以克服有机对等物的广泛问题-光漂白。但是，当前的PUCNP仅遵循Yb 3+ / Nd 3+共敏化模式，这会导致复杂的多层掺杂模式以及在UV-蓝色区域中切换的不完善性。在这项工作中，我们采用了一种新的策略来构建Nd 3+的免费PUCNPs-NaErF 4 @NaYF 4 @NaYbF 4：0.5％[电子邮件保护] 4。这些PUCNP证明了光电开关的优越性能。Tm 3+产生明显的紫外-蓝色辐射在980 nm的激发下开启，可以被800 nm的光完全关闭。800 nm激发下的准单色红色上转换发射-未掺杂NaErF 4的显着特征上转换系统-为PUCNP提供了有前途的图像指导的生物医学光诱导“关闭”疗法。作为概念验证，我们已经证明了癌症的成像指导光动力疗法（PDT），其中800 nm的激发会关闭UV-蓝色发射，而将发射保持在660 nm进行成像。一旦确定了肿瘤部位，激发切换到980 nm会导致UV蓝光发射和红光发射。前者用于诱导PDT，而后者则用于监测治疗过程。我们的研究表明，这种上转换光开关材料适用于时空控制下的实时成像和图像指导治疗。
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