### [Miller et al. Page 650][1] A novel DNA alkylating payload of antibody-drug conjugates (ADCs) was designed and evaluated in preclinical cancer models by Millers and colleagues. Changing the mechanism of action of the cytotoxic agent from a crosslinker to a DNA alkylator, along with linker

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本期要点

### [Miller等。Page 650] [1]由Millers和同事在临床前癌症模型中设计和评估了抗体-药物偶联物（ADC）的新型DNA烷基化有效负载。将细胞毒性剂的作用机理与连接剂一起从交联剂转变为DNA烷基化剂