Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α,Theranostics

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Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α
Theranostics ( IF 12.4 ) Pub Date : 2018-01-01 , DOI: 10.7150/thno.22237
Feng Zhang _{1,

2,

3} , Shuai Lu ₄ , Jianlin He ₅ , Huanhuan Jin ₁ , Feixia Wang ₁ , Li Wu _{1,

2,

3} , Jiangjuan Shao _{2,

3} , Anping Chen ₆ , Shizhong Zheng _{1,

2,

3}

Affiliation

Rationale: Hepatic stellate cells (HSCs) are liver-specific pericytes regulating vascular remodeling during hepatic fibrosis. Here, we investigated how ligustrazine affects HSC pericyte functions.

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