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CDK16 Phosphorylates and Degrades p53 to Promote Radioresistance and Predicts Prognosis in Lung Cancer
Theranostics ( IF 12.4 ) Pub Date : 2018-01-01 , DOI: 10.7150/thno.21963
Jie Xie , Yan Li , Ke Jiang , Kaishun Hu , Sheng Zhang , Xiaorong Dong , Xiaofang Dai , Li Liu , Tao Zhang , Kunyu Yang , Kai Huang , Junjie Chen , Shaojun Shi , Yu Zhang , Gang Wu , Shuangbing Xu

Rationale: Radioresistance is considered the main cause of local relapse in lung cancer. However, the molecular mechanisms of radioresistance remain poorly understood. This study investigates the role of CDK16 in radioresistance of human lung cancer cells.

中文翻译:

CDK16磷酸化并降解p53以促进放射抵抗并预测肺癌的预后。

理由:放射抵抗被认为是肺癌局部复发的主要原因。但是,抗辐射的分子机制仍然知之甚少。这项研究调查了CDK16在人类肺癌细胞的放射抵抗中的作用。
更新日期:2018-03-01
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