Enhanced Synergism of Thermo-chemotherapy For Liver Cancer with Magnetothermally Responsive Nanocarriers,Theranostics

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Enhanced Synergism of Thermo-chemotherapy For Liver Cancer with Magnetothermally Responsive Nanocarriers
Theranostics ( IF 12.4 ) Pub Date : 2018-01-01 , DOI: 10.7150/thno.21297
Minghua Li ₁ , Wenbo Bu ₂ , Jie Ren ₃ , Jianbo Li ₃ , Li Deng ₃ , Mingyuan Gao ₄ , Xiaolong Gao ₁ , Peijun Wang ₁

Affiliation

A combination of magnetic hyperthermia and magnetothermally-facilitated drug release system was developed as a promising strategy for liver cancer therapy. The thermosensitive copolymer, 6sPCL-b-P(MEO₂MA-co-OEGMA) shows a good temperature-controlled drug release response. Mn-Zn ferrite magnetic nanoparticles (MZF-MNPs) exhibit a strong magnetic thermal effect with an alternating magnetic field (AMF). Owing to its high magnetic sensitivity, the magnetothermally-responsive nanocarrier/doxorubicin (MTRN/DOX) can be concentrated in the tumor site efficiently through magnetic targeting. Given this information, we synthesized MTRN/DOX which was composed of MZF-MNPs, thermosensitive copolymer drug carriers, and the chemotherapeutic drug---DOX, to study its anticancer effects both in vitro and in vivo.

中文翻译：

磁热响应纳米载体增强肝癌热化疗的协同作用

磁热疗和磁热促进药物释放系统的结合被开发为肝癌治疗的一种有前景的策略。热敏共聚物6sPCL- b -P(MEO ₂ MA-co-OEGMA)表现出良好的温控药物释放响应。锰锌铁氧体磁性纳米粒子（MZF-MNPs）在交变磁场（AMF）下表现出强磁热效应。由于其高磁敏感性，磁热响应纳米载体/阿霉素（MTRN/DOX）可以通过磁靶向有效地集中在肿瘤部位。鉴于此，我们合成了由MZF-MNPs、热敏共聚物药物载体和化疗药物DOX组成的MTRN/DOX，以研究其体外和体内的抗癌作用。

更新日期：2018-03-01

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