Objective: Monitoring emerging vascular-targeted photodynamic therapy (VTP) and understanding the time-dynamics of treatment effects remains challenging. We interrogated whether handheld multispectral optoacoustic tomography (MSOT) could noninvasively monitor the effect of VTP using WST11, a vascular-acting photosensitizer, on tumor tissues over time using a renal cell cancer mouse model. We also investigated whether MSOT illumination can induce VTP, to implement a single-modality theranostic approach.

中文翻译：

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多光谱光声层析成像（MSOT）监测WST11血管靶向光动力疗法的疗效。

目的：监测新兴的以血管为靶标的光动力疗法（VTP）并了解治疗效果的时间动态性仍然具有挑战性。我们询问了手持多光谱光声层析成像（MSOT）是否可以使用肾细胞癌小鼠模型随时间推移使用WST11（一种血管作用光敏剂）对肿瘤组织进行无创监测VTP的效果。我们还调查了MSOT照明是否可以诱导VTP，以实施单模态治疗方法。