Fluorescence image-guided surgery combined with intraoperative therapeutic modalities has great potential for intraoperative detection of oncologic targets and eradication of unresectable cancer residues. Therefore, we have developed an activatable theranostic nanoplatform that can be used concurrently for two purposes: (1) tumor delineation with real-time near infrared (NIR) fluorescence signal during surgery, and (2) intraoperative targeted treatment to further eliminate unresected disease sites by non-toxic phototherapy.

中文翻译：

---

NIR荧光引导手术和组合光疗的肿瘤激活的治疗学纳米医学平台。

荧光图像引导手术结合术中治疗方法在术中检测肿瘤靶标和根除不可切除的癌残留物方面具有巨大潜力。因此，我们开发了可同时用于两个目的的可激活的治疗性纳米平台：（1）在手术过程中通过实时近红外（NIR）荧光信号进行肿瘤描绘，以及（2）术中靶向治疗以进一步消除未切除的疾病部位通过无毒的光疗。