Purpose: Transcatheter hepatic artery embolization therapy is a minimally invasive alternative for treating inoperable liver cancer but recurrence is frequent. Multifunctional agents, however, offer an opportunity for tumor eradication. In this study, we were aim to synthesized poly (lactic-co-glycolic acid) (PLGA) microspheres encapsulating hollow CuS nanoparticles (HCuSNPs) and paclitaxel (PTX) that were then labeled with radioiodine-131 (¹³¹I) to produce ¹³¹I-HCuSNPs-MS-PTX. This compound combines the multi-theranostic properties of chemotherapy, radiotherapy and photothermal therapy. In addition, it can also be imaged with single photon emission computed tomography (SPECT) imaging and photoacoustic imaging.

中文翻译：

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¹³¹ I-标记的硫化铜微球通过肝动脉栓塞治疗肝肿瘤

目的：经导管肝动脉栓塞治疗是治疗无法手术的肝癌的一种微创替代方法，但复发率很高。然而，多功能剂为消灭肿瘤提供了机会。在这项研究中，我们旨在合成封装空心CuS纳米颗粒（HCuSNPs）和紫杉醇（PTX）的聚乳酸-乙醇酸乙醇（PLGA）微球，然后用放射性碘131（¹³¹ I）标记以产生¹³¹ I -HCuSNPs-MS-PTX。该化合物结合了化学疗法，放射疗法和光热疗法的多种热疗特性。此外，它还可以通过单光子发射计算机断层扫描（SPECT）成像和光声成像进行成像。