Mesenchymal stem cells (MSC) are highly immunosuppressive cells able to reduce chronic inflammation through the active release of mediators. Recently, we showed that glucocorticoid-induced leucine zipper (Gilz) expression by MSC is involved in their therapeutic effect by promoting the generation of regulatory T cells. However, the mechanisms underlying this pivotal role of Gilz remain elusive.

中文翻译：

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Gilz-Activin A作为新型信号轴协调间充质干细胞和Th17细胞相互作用。

间充质干细胞（MSC）是高度免疫抑制细胞，能够通过主动释放介质来减轻慢性炎症。最近，我们发现MSC糖皮质激素诱导的亮氨酸拉链（Gilz）表达通过促进调节性T细胞的产生而参与其治疗效果。但是，Gilz发挥关键作用的机制仍然难以捉摸。