2‐Hydroxybenzophenone as a Chemical Auxiliary for the Activation of Ketiminoesters for Highly Enantioselective Addition to Nitroalkenes under Bifunctional Catalysis,Angewandte Chemie International Edition

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2‐Hydroxybenzophenone as a Chemical Auxiliary for the Activation of Ketiminoesters for Highly Enantioselective Addition to Nitroalkenes under Bifunctional Catalysis
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-04-14 , DOI: 10.1002/anie.201800435
Andrea Guerrero-Corella ₁ , Francisco Esteban ₁ , Manuel Iniesta ₁ , Ana Martín-Somer ₂ , Mario Parra ₁ , Sergio Díaz-Tendero _{2,

3,

4} , Alberto Fraile _{1,

3} , Jose Alemán _{1,

3}

Affiliation

An organocatalytic system is presented for the Michael addition of monoactivated glycine ketimine ylides with a bifunctional catalyst. The ketimine bears an ortho hydroxy group, which increases the acidity of the methylene hydrogen atoms and enhances the reactivity, thus allowing the synthesis of a large variety of α,γ‐diamino acid derivatives with excellent stereoselectivity.

中文翻译：

2-羟基二苯甲酮作为化学助剂，用于活化酮亚酯，在双功能催化下对硝基烯烃进行高度对映选择性加成

提出了一种用于单活化甘氨酸酮亚胺叶立德与双功能催化剂的迈克尔加成的有机催化体系。酮亚胺带有邻羟基，增加了亚甲基氢原子的酸性并增强了反应活性，从而可以合成多种具有优异立体选择性的α,γ-二氨基酸衍生物。

更新日期：2018-04-14

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