Metal‐Free Multicomponent Reaction for Synthesis of 4,5‐Disubstituted 1,2,3‐(NH)‐Triazoles,Advanced Synthesis & Catalysis

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Metal‐Free Multicomponent Reaction for Synthesis of 4,5‐Disubstituted 1,2,3‐(NH)‐Triazoles
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-04-03 , DOI: 10.1002/adsc.201701587
Guang-Long Wu ₁ , Qin-Pei Wu ₁

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A metal‐free domino reaction was developed for efficient synthesis of 4,5‐disubstituted 1,2,3‐(NH)‐triazoles by sequentially coupling sulfur salts with aldehydes and sodium azide. In the presence of L‐proline, olefinic sulfur salt intermediates rather than epoxides are formed in situ via the coupling of sulfur salts with aldehydes and cyclize with azide ion. This process features mild conditions, high efficiency, commercially available starting materials, and wide substrate scope.

中文翻译：

无金属多组分反应用于合成4,5-二取代1,2,3-（NH）-三唑

通过顺序地将硫盐与醛和叠氮化钠偶联，开发了一种无金属的多米诺反应，可有效合成4,5-二取代的1,2,3-（NH）-三唑。在L-脯氨酸存在下，通过硫盐与醛的偶合并与叠氮化物离子环合，就可以在原位形成烯属硫盐中间体而不是环氧化物。该工艺具有温和的条件，高效率，可商购的起始原料以及广泛的底物范围。

更新日期：2018-04-03

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