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Ni‐Catalyzed C−F Bond Functionalization of Unactivated Aryl Fluorides and Corresponding Coupling with Oxazoles
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-03-09 , DOI: 10.1002/adsc.201701506
Youzhi Yin 1 , Xiaoyu Yue 2 , Qi Zhong 1 , Hanmin Jiang 1 , Ruopeng Bai 2 , Yu Lan 2 , Hua Zhang 1
Affiliation  

A Ni‐catalyzed C−F bond functionalization of unactivated aryl fluorides with oxazoles as coupling partners was developed. Various arylated oxazoles could be obtained in moderate to good yields in the presence of Ni(cod)2/IMes catalytic system. A rapid synthesis of natural product texaline was also demonstrated using this protocol. This transformation could be potentially utilized in regioselective introduction of an oxazole group in late‐stage synthetic applications.

中文翻译:

镍催化未活化芳基氟化物的CF键官能化以及与恶唑的相应偶联

已开发了以恶唑为偶合伴侣的未活化芳基氟化物的Ni催化C-F键官能化。在Ni(cod)2 / IMes催化体系存在下,可以以中等至良好的产率获得各种芳基化的恶唑。使用该方案还证明了天然产物texaline的快速合成。该转化可潜在地用于后期合成应用中恶唑基的区域选择性引入。
更新日期:2018-03-09
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