Ni‐Catalyzed C−F Bond Functionalization of Unactivated Aryl Fluorides and Corresponding Coupling with Oxazoles,Advanced Synthesis & Catalysis

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Ni‐Catalyzed C−F Bond Functionalization of Unactivated Aryl Fluorides and Corresponding Coupling with Oxazoles
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-03-09 , DOI: 10.1002/adsc.201701506
Youzhi Yin ₁ , Xiaoyu Yue ₂ , Qi Zhong ₁ , Hanmin Jiang ₁ , Ruopeng Bai ₂ , Yu Lan ₂ , Hua Zhang ₁

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A Ni‐catalyzed C−F bond functionalization of unactivated aryl fluorides with oxazoles as coupling partners was developed. Various arylated oxazoles could be obtained in moderate to good yields in the presence of Ni(cod)₂/IMes catalytic system. A rapid synthesis of natural product texaline was also demonstrated using this protocol. This transformation could be potentially utilized in regioselective introduction of an oxazole group in late‐stage synthetic applications.

中文翻译：

镍催化未活化芳基氟化物的CF键官能化以及与恶唑的相应偶联

已开发了以恶唑为偶合伴侣的未活化芳基氟化物的Ni催化C-F键官能化。在Ni（cod）₂ / IMes催化体系存在下，可以以中等至良好的产率获得各种芳基化的恶唑。使用该方案还证明了天然产物texaline的快速合成。该转化可潜在地用于后期合成应用中恶唑基的区域选择性引入。

更新日期：2018-03-09

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