Front Cover: Alkoxy Tetrazine Substitution at a Boron Center: A Strategy for Synthesizing Highly Fluorogenic Hydrophilic Probes (ChemBioChem 6/2018),ChemBioChem

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Front Cover: Alkoxy Tetrazine Substitution at a Boron Center: A Strategy for Synthesizing Highly Fluorogenic Hydrophilic Probes (ChemBioChem 6/2018)
ChemBioChem ( IF 2.6 ) Pub Date : 2018-02-28 , DOI: 10.1002/cbic.201800102
Min Wu ₁ , Xiaoai Wu ₂ , Yayue Wang ₁ , Lei Gu ₁ , Jiao You ₁ , Haoxing Wu ₁ , Ping Feng ₃

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The front cover picture shows the generation of BODIPY turn‐on probes by introducing alkoxy tetrazines at the boron center of the BODIPY scaffold. This method endows the probes with the high water solubility and endows the bioorthogonal partner—TCO— with strongly fluorogenic properties. Using designed probes to detect TCO‐decorated antibodies on cells provides further insights into their application in live‐cell imaging. More information can be found in the full paper by H. Wu, P. Feng, et al. on page 530 in Issue 6, 2018 (DOI: 10.1002/cbic.201700556).

中文翻译：

封面：硼中心的烷氧基四嗪取代：合成高氟亲水性探针的策略（ChemBioChem 6/2018）

封面图片显示了通过在BODIPY支架的硼中心引入烷氧基四嗪生成BODIPY开启探针的过程。这种方法赋予探针高水溶性，并赋予生物正交配体TCO强烈的荧光特性。使用设计的探针检测细胞上TCO修饰的抗体，可以进一步了解其在活细胞成像中的应用。有关更多信息，请参见H. Wu，P。Feng等人的全文。就在第6期，2018页面530（：10.1002 / cbic.201700556 DOI）。

更新日期：2018-02-28

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