Graphene oxide as a dual Zn/Mg ion carrier and release platform: enhanced osteogenic activity and antibacterial properties,Journal of Materials Chemistry B

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Graphene oxide as a dual Zn/Mg ion carrier and release platform: enhanced osteogenic activity and antibacterial properties
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2018-02-28 00:00:00 , DOI: 10.1039/c8tb00162f
Jiajun Qiu _{1,

2,

3,

4,

5} , Lu Liu _{1,

2,

3,

4,

5} , Baohui Chen _{1,

2,

3,

4,

5} , Yuqin Qiao _{1,

2,

3,

4,

5} , Huiliang Cao _{1,

2,

3,

4,

5} , Hongqin Zhu _{1,

2,

3,

4,

5} , Xuanyong Liu _{1,

2,

3,

4,

5}

Affiliation

Implant failure of titanium and its alloys still occurs due to insufficient osseointegration and implant associated infections. Therefore, titanium implants with enhanced osseointegration and antibacterial activities are desirable. To achieve this goal, graphene oxide (GO) as a dual zinc/magnesium (Zn/Mg) ion carrier and release platform was constructed on the titanium surface by cathode electrophoresis deposition. Rat bone mesenchymal stem cells were used to investigate the osteogenic activity. Gram-negative E. coli was utilized to assess the antibacterial activities. Results show that GO co-doped with Mg and Zn ions with a sustained and slow release exhibited the best osteogenic activity among all the samples by stimulating the expressions of osteogenesis related genes containing alkaline phosphatase (ALP), type I collagen (Col-I), osteocalcin (OCN), and osteopontin (OPN), and by promoting the alkaline phosphatase activity and extracellular matrix mineralization. The existence of GO endowed titanium with superior antibacterial activities against Gram-negative E. coli. Due to the synergistic effects of GO, Mg and Zn ions, a titanium surface with enhanced osseointegration and antibacterial activities was achieved.

中文翻译：

氧化石墨烯作为锌/镁双重离子载体和释放平台：增强的成骨活性和抗菌性能

钛及其合金的植入失败仍然是由于骨整合不足和植入相关感染引起的。因此，期望具有增强的骨整合和抗菌活性的钛植入物。为了实现这个目标，通过阴极电泳沉积在钛表面上构建了氧化锌（GO）作为锌/镁（Zn / Mg）双重离子载体和释放平台。使用大鼠骨间充质干细胞研究成骨活性。革兰氏阴性大肠杆菌用于评估抗菌活性。结果表明，通过刺激含有碱性磷酸酶（ALP），I型胶原（Col-I）的成骨相关基因的表达，GO与镁和锌离子共掺杂并持续释放和缓慢释放，表现出最佳的成骨活性。，骨钙蛋白（OCN）和骨桥蛋白（OPN），并通过促进碱性磷酸酶活性和细胞外基质矿化来实现。GO的存在赋予了钛对革兰氏阴性大肠杆菌优异的抗菌活性。由于GO，Mg和Zn离子的协同作用，获得了具有增强的骨整合和抗菌活性的钛表面。

更新日期：2018-02-28

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