当前位置：
X-MOL 学术
›
Chem. Sci.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
A mitochondria-targeted nanoradiosensitizer activating reactive oxygen species burst for enhanced radiation therapy†
Chemical Science ( IF 7.6 ) Pub Date : 2018-02-28 00:00:00 , DOI: 10.1039/c7sc04458e Na Li 1 , Longhai Yu 1 , Jianbo Wang 2 , Xiaonan Gao 1 , Yuanyuan Chen 1 , Wei Pan 1 , Bo Tang 1
Chemical Science ( IF 7.6 ) Pub Date : 2018-02-28 00:00:00 , DOI: 10.1039/c7sc04458e Na Li 1 , Longhai Yu 1 , Jianbo Wang 2 , Xiaonan Gao 1 , Yuanyuan Chen 1 , Wei Pan 1 , Bo Tang 1
Affiliation
|
Radiation therapy (RT) has been widely used for malignant tumor treatment. However, the large dosage of ionizing radiation and high frequency of radiotherapy in clinical cancer therapy cause severe damage to normal tissues adjacent to tumors. Therefore, how to increase the local treatment efficacy and reduce the damage to normal tissues has been a challenge for RT. Herein, we developed a novel strategy for enhanced RT based on a mitochondria targeted titanium dioxide-gold nanoradiosensitizer. When irradiated with X-rays, the nanosensitizer could produce reactive oxygen species (ROS) in the mitochondria, which induced the domino effect on the ROS burst. The overproduced ROS accumulated in mitochondria, resulting in mitochondrial collapse and irreversible cell apoptosis. A colony formation assay indicated that the cell survival rate when incubated with the mitochondrial targeted nanosensitizer was significantly lower than that of non-targeted groups. As demonstrated by in vivo experiments, the tumor was significantly suppressed even just once RT with the nanosensitizer.
中文翻译：
一种靶向线粒体的纳米放射增敏剂激活活性氧爆发以增强放射治疗†
放射治疗（RT）已广泛用于恶性肿瘤的治疗。然而，临床癌症治疗中电离辐射的大剂量和高频率的放疗对肿瘤邻近的正常组织造成了严重的损伤。因此，如何提高局部治疗效果并减少对正常组织的损伤一直是放射治疗面临的挑战。在此，我们开发了一种基于线粒体靶向二氧化钛-金纳米放射增敏剂的增强 RT 的新策略。当受到X射线照射时，纳米敏化剂可以在线粒体中产生活性氧（ROS），从而引发ROS爆发的多米诺骨牌效应。过量产生的ROS在线粒体中积累，导致线粒体崩溃和不可逆的细胞凋亡。集落形成测定表明，与线粒体靶向纳米敏化剂一起孵育时的细胞存活率显着低于非靶向组。正如体内实验所证明的那样，即使仅使用纳米敏化剂进行一次RT，肿瘤也被显着抑制。
更新日期：2018-02-28
中文翻译：
一种靶向线粒体的纳米放射增敏剂激活活性氧爆发以增强放射治疗†
放射治疗（RT）已广泛用于恶性肿瘤的治疗。然而，临床癌症治疗中电离辐射的大剂量和高频率的放疗对肿瘤邻近的正常组织造成了严重的损伤。因此，如何提高局部治疗效果并减少对正常组织的损伤一直是放射治疗面临的挑战。在此，我们开发了一种基于线粒体靶向二氧化钛-金纳米放射增敏剂的增强 RT 的新策略。当受到X射线照射时，纳米敏化剂可以在线粒体中产生活性氧（ROS），从而引发ROS爆发的多米诺骨牌效应。过量产生的ROS在线粒体中积累，导致线粒体崩溃和不可逆的细胞凋亡。集落形成测定表明，与线粒体靶向纳米敏化剂一起孵育时的细胞存活率显着低于非靶向组。正如体内实验所证明的那样，即使仅使用纳米敏化剂进行一次RT，肿瘤也被显着抑制。
京公网安备 11010802027423号