Two new inorganic-organic hybrid materials based on heteropolyoxometalates (POMs): (C₄H₁₀N)₆[P₂Mo₁₈O₆₂]·4H₂O (P₂Mo₁₈) and (C₆H₈NO)₄[H₂P₂W₁₈O₆₂]·6H₂O (P₂W₁₈) are reported as mediators for electron transfer between FAD-dependent glucose dehydrogenase (FAD-GDH) and a multiwalled carbon nanotube (MWCNT) matrix for glucose biofuel cell and biosensor applications. These polyoxometalates were chosen due to their promising redox behavior in a potential range for mediated electron transfer with the glucose oxidizing enzyme, FAD-GDH. P₂Mo₁₈ and P₂W₁₈ were immobilized on 1-pyrenemethylamine (PMA) functionalized MWCNT deposits. After immobilization of FAD-GDH, the P₂W₁₈-modified MWCNT electrode demonstrated mediated electron transfer and provided a catalytic current density of 0.34 mA cm⁻² at 0.2 V vs SCE with an open circuit potential (OCP) of −0.08 V vs SCE. A 10-fold increase in catalytic current to 4.7 mA cm⁻² at 0.2 V vs SCE and a slightly lower OCP of −0.10 V vs SCE was observed for an equivalent electrode modified with P₂Mo₁₈.The apparent superiority of P₂Mo₁₈ is related, at least in part, to its improved incorporation in the MWCNT matrix compared to P₂W₁₈. Both POM-modified bioanodes showed exceptional stabilities with 45% of their initial performances remaining after 15 days. The mediated electron transfer capacities of the POMs were also evaluated in a glucose sensor setup and showed very satisfying performances for glucose detection, including a sensitivity of 0.198 mA mol L⁻¹ cm⁻², a satisfying linear range between 1 mmol L⁻¹ and 20 mmol L⁻¹, and good reproducibility for the P₂Mo₁₈ electrode.

基于杂多金属氧酸盐（POM）的两种新型无机-有机杂化材料：（C ₄ H ₁₀ N）₆ [P ₂ Mo ₁₈ O ₆₂ ]·4H ₂ O（P ₂ Mo ₁₈）和（C ₆ H ₈ NO）₄ [ H ₂ P ₂ W ₁₈ O ₆₂ ]·6H ₂ O（P ₂ W ₁₈）被报道为FAD依赖性葡萄糖脱氢酶（FAD-GDH）和用于葡萄糖生物燃料电池和生物传感器应用的多壁碳纳米管（MWCNT）基质之间电子转移的介体。选择这些多金属氧酸盐是因为它们在氧化葡萄糖酶FAD-GDH介导的电子转移的潜在范围内具有良好的氧化还原行为。将P ₂ Mo ₁₈和P ₂ W ₁₈固定在1-py甲基胺（PMA）功能化的MWCNT沉积物上。固定FAD-GDH后，P ₂ W ₁₈修饰的MWCNT电极表现出介导的电子转移，并提供0.34 mA cm ^-2的催化电流密度在0.2 V vs SCE的情况下，开路电势（OCP）在-0.08 V vs SCE的情况下。在催化电流4.7毫安厘米有10倍增加^-2观察到的P改性的等效电极以0.2V相对于SCE和-0.10的V相对于SCE稍低OCP ₂沫₁₈ P的.The表观优越性₂沫_图18至少部分地涉及与P ₂ W ₁₈相比其在MWCNT基体中的改进的结合。。两种POM修饰的生物阳极均表现出出色的稳定性，在15天后仍保留其初始性能的45％。还通过葡萄糖传感器设置评估了POM的介导电子转移能力，并显示出非常令人满意的葡萄糖检测性能，包括0.198 mA mol L ^-1 cm ^-2的灵敏度，1 mmol L ^-1和1 mmol L的令人满意的线性范围。20 mmol L ^-1，对于P ₂ Mo ₁₈电极具有良好的重现性。